Trytophan - The Biochemical Depression Cure.

When a person suffers from biochemically-induced depression, counseling and psychotherapy treatments from even the greatest doctors are doomed to fail. That’s because words have no power to cure the biochemical disruption in the brain, which causes the affliction. For many, depression is known as a direct result of tragic external events. However, research studies have also proven a relationship between biochemistry and depression. For instance, depression may stem from the damaging effects of alcohol on the brain’s chemistry.

Related posts:
Overcoming Depression So You Can Feel Like Yourself Again.
Overcoming Depression So You Can Feel Like Yourself Again.

[...]Depression can stem from a traumatic event, a biochemical cause, or from personal problems. Often, depression is caused by unrest (or turmoil) in your personality or way of thinking.

Let me share some examples. When my father died, I grieved deeply. I felt like a part of me had died. One of my patients, Alec, also felt a sense of loss, although his circumstances were different. He was unexpectedly fired from his job, and felt bewildered and disoriented. Another client, Sam, felt depressed when his house burned to the ground, and he lost everything that mattered to him.

When unpleasant things like this happen, it is hard to think straight and know what to do next. Remember that all emotions have a lifespan. Give yourself time and permission to grieve, and feel those feelings. Often, the feelings will fade away with time, and you will heal and feel like yourself again.[...]

To be sure of the best possible cure for this illness, one has to first determine the cause for depression. Biochemical depression has specific symptoms that separate it from the kind that stems from negative life events. You might be biochemically depressed if any of the following describes your depression:

  1. Despite changes and improvements in your life, you have been depressed for a long time
  2. Good news do not elicit any reaction from you
  3. Talk therapy produces little or no effect at all. When asked questions like “Why do you hate your parents?” you get confused and clueless for an answer
  4. You wake up very early in the morning and can’t get back to sleep
  5. You do not remember when you started being depressed and cannot associate the onset of your depression to any event in your life
  6. Your experience severe mood swings, ranging from elation to depression over a period of months (this suggests bipolar, or manic-depressive, disorder)
  7. Heavy drinking makes your depression worse
Related posts:
Which Came First - Depression or Diabetes?
Which Came First - Depression or Diabetes?

[...]However, some antidepressant medications have common side effects that duplicate risk factors for type 2 diabetes. TCA’s, for example, are associated with weight gain and may increase blood glucose levels. (SSRI’s, on the other hand, are not associated with weight gain and may actually improve insulin sensitivity.) No study has been able to explain the mechanism by which antidepressant medications may influence the onset of type 2 diabetes. Some researchers suggest that antidepressant use may just be a marker for a history of recurrent or severe depression, which may have physiologic and biochemical effects on the body that leads to impaired glucose tolerance.

To confound the proverbial chicken-and-egg debate, the study published in JAMA demonstrated that patients treated for type 2 diabetes were at risk for developing depressive symptoms. These patients were also more likely to have high blood pressure and protein in their urine, suggestive of kidney damage. Interestingly, patients with pre-diabetes, or impaired fasting glucose, and patients with type 2 diabetes who were not being treated were less likely to experience depression.[...]

One cause for biochemical depression is the depletion of two major neurotransmitters that prevent depression from kicking in: serotonin (converted from the amino acid L-tryptophan) and norepinephrine (converted from the amino acids L-phenylalanine and L-tyrosine). These chemical substances control our memory, sleep, behavior, moods, emotions and learning abilities. When these neurotransmitters are depleted because of damaging substances such as alcohol, depression set in. This can be cured by taking daily amino acid supplements.

The kind of supplement a patient needs to take depends on the symptoms that he feels. For people who experience insomnia, depression and anxiety, taking tryptophan is the closest you could get to a wonder pill. Fortunately, trytophan doesn’t have to come in the form of a capsule. It is an amino acid found in large quantities in turkey and milk. Trytohpan is the nutrient required to form serotonin, which in turn controls mood, sex drive, appetite, sleep, and pain threshold.

Here are the guidelines for taking trytophan:

  1. Taking tryptophan alone does not automatically convert into to serotonin. It must be taken with vitamin C and vitamin B6
  2. Tryptophan first turns into niacin before it gets converted into serotonin. If your body lacks niacin, tryptophan will supply the deficiency, and not turn into serotonin. Hence, it is best to also take a B-complex vitamin daily. This will give you both vitamin B6 and niacin and allow the tryptophan to be converted to serotonin.
  3. Inositol changes into a substance that regulates serotonin’s effectiveness within nerve cells.Studies confirm its effectiveness with depression. Inositol should be included in this formula.
Related posts:
Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine.

[...]Biochemical studies revealed compromised serotonergic transmission in the raphe-hippocampal serotonergic pathway: decrease of serotonin (5-HT) concentration and turnover in the hippocampus, measured by high performance liquid chromatography, and decrease of 5-HT release from the hippocampus in response to raphe stimulation, measured by fast cyclic voltammetry. Administration of fluoxetine (FLX, 20 mg/kg/day for 10 days) to naive animals significantly shortened immobility time under conditions of FST, and inhibited 5-HT turnover in the hippocampus. In post-SE rats FLX treatment led to a further decrease of hippocampal 5-HT turnover; however, performance in FST was not improved. At the same time, FLX reversed SE-induced increase in brain excitability. In summary, our studies provide initial evidence that post-SE model of TLE might serve as a model of the comorbidity of epilepsy and depression[...]

Of all the amino acids, tryptophan is the least capable of crossing the blood-brain barrier. It has to surpass this biological hindrance before it could turn into serotonin. You can give it an extra push by taking it with fruit juice. This increases insulin release, which will assist the tryptophan across the blood-brain barrier. Lastly, always take your tryptophan on an empty stomach.

Sam Summers writes for Annihilate Anxiety. He grew up with GAD (generalized anxiety disorder), and used to be very awkward in social situations. During adolescence, he could not even work up the courage to ask out his high school crush! Although he was painfully shy growing up, with the help of his friends and family, Sam has managed to overcome his anxiety. Today, Sam counsels other adults, adolescents, and even children in overcoming their anxiety and fears. You can find his writings and work at AnnihilateAnxiety.com

Sam also helps others with overcoming shyness.

2 Responses to “Trytophan - The Biochemical Depression Cure.”

  1. I don’t get it. How does something like that work?

  2. I read somewhere that petai has lots of tryptophan content.

    PS: Petai can be easily found in SEA and very popular in Malaysia.

Leave a Reply

You can use these XHTML tags: <a href="" title=""> <abbr title=""> <acronym title=""> <blockquote cite=""> <code> <em> <strong>